immunotherapy for osteoarthritis
As part of a clinical department we have access to rare clinical samples. We are studying immune profiles of synovial fluid from patients with osteoarthritis. We believe that this work will result in the creation of multiple novel immunotherapeutic strategies to augment surgery or prolong the need for surgical interventions in this patient population.
The Thaxton Lab's first osteoarthritis paper is under review!
Characterization of Immune Subsets in Synovial Fluid of Advanced Osteoarthritis Patients
Molly G. Sekar, Kiley A. Lawrence, Thomas Valente, Gabriella Santa Lucia, Matthew T. Essman, Katie E. Hurst, William Barfield, Lee R. Leddy, Zeke J. Walton, Vincent D. Pellegrini Jr., Jessica E. Thaxton.
Under review, May 2019.
Figure 5. Characterization of synovial macrophages. A) Representative FACS plots and quantification of autologous-matched samples from PBMC and SF of OA patients assessed for CD45/ CD11b/ CD14+/ CD15- expression or B) quantified for CD45/ CD11b/ CD14-/ CD15+ status. C) Representative FACS plots and quantification of autologous-matched samples from PBMC and SF of OA patients assessed for CD45/ CD11b/ CD14+/ HLADR+ expression. Lines represent connection between autologous-matched samples. Gates are set from fluorescence minus one controls.