Cell Stress Signaling Responses in Tumor Immunity

​

Our laboratory studies the mechanisms through which immune cells in tumors experience tumor microenvironment (TME) stress.  We have found that TME stressors such as hypoxia enforce ER stress proteins in T cells and macrophages in tumors promoting cellular dysfunction, such as T cell exhaustion. We utilize Opal multiplex immunofluorescent imaging, spectral flow cytometry, metabolomics, Seahorse Bioanalysis, tumor mouse models and patient samples to study the chronic stress response in tumor immunity.