Metabolic stress relief for cancer immunotherapy: Implications for the ER stress response in tumor immunity. Andrews AM, Tennant MD, Thaxton JE. Metabolic stress relief for cancer immunotherapy. Cancer Immunology and Immunotherapy, In Press. Forthcoming

Differentiating macrophages are regulated by PARP inhibitors and can be harnessed to overcome PARP-inhibitor resistance in BRCA-associated triple-negative breast cancer. Mehta AK, Cheney EM, Hartl CA, Pantelidou C, Oliwa M, Castrillon JA, Lin J, Hurst KE, de Oliveira Taveira M, Johnson N, Oldham W, Thaxton JE, Mittendorf EA, Shapiro GI, Sorger PK, Guerriero JL. Nature Cancer, In Press. Forthcoming

Ex vivo blockade of PI3K gamma or delta signaling enhances the antitumor potency of adoptively transferred CD8+ T cells. Dwyer CJ, Arhontoulis DC, Rangel Rivera GO, Knochelmann HM, Smith AS, Wyatt MM, Rubinstein MP, Atkinson C, Thaxton JE, Neskey DM, Paulos CM. Eur J Immunol. 2020 May 08

An observational study and randomized trial of stress reactivity in cancer disparities. Hughes-Halbert C, Jefferson MS, Danielson CC, Foglier B, Giordano A, Thaxton JE. Health Psychol. 2020 Sep;39(9):745-757. doi: 10.1037/hea0000882. PubMed PMID: 32833476

Remodeling Translation Primes CD8+ T Cell Antitumor Immunity. Hurst KE, Lawrence KA, Robino RA, Ball LE, Chung D, Thaxton JE. Cancer Immunol Res. 2020 May;8(5):587-595. doi: 10.1158/2326-6066.CIR-19-0516. Epub 2020 Feb 19. PubMed PMID: 32075802.

 

Endoplasmic Reticulum Protein Disulfide Isomerase Shapes T Cell Efficacy for Adoptive Cellular Therapy of Tumors. Hurst KE, Lawrence KAReyes Angeles LYe ZZhang JTownsend DMDolloff N, Thaxton JECells. 2019 Nov 26;8(12). pii: E1514. doi: 10.3390/cells8121514

 

Endoplasmic reticulum stress contributes to mitochondrial exhaustion of T cells. Hurst, KE, Lawrence, KA, Essman, MT, Walton, ZJ, Leddy, LR, Thaxton, JE. Cancer Immunol Res. 2019 Mar;7(3):476-486. doi: 10.1158/2326-6066.CIR-18-0182. Epub 2019 Jan 18. PMID:30659052

Modulation of endoplasmic reticulum stress controls CD4+ T-cell activation and antitumor function. Thaxton JE, Wallace C, Riesenberg B, Zhang Y, Paulos CM, Beeson CC, Liu B, Li Z. Cancer Immunol Res. 2017 Aug;5(8):666-675. doi: 10.1158/2326-6066.CIR-17-0081. Epub 2017 Jun 22. PMID:28642246

 

Clients and oncogenic roles of molecular chaperone gp96/grp94. Ansa-Addo EA, Thaxton J, Hong F, Wu BX, Zhang Y, Fugle CW, Metelli A, Riesenberg B, Williams K, Gewirth DT, Chiosis G, Liu B, Li Z. Curr Top Med Chem. 2016;16(25):2765-78. Review. PMID:27072698

 

GP96 is a GARP chaperone and controls regulatory T cell functions. Zhang Y, Wu BX, Metelli A, Thaxton JE, Hong F, Rachidi S, Ansa-Addo E, Sun S, Vasu C, Yang Y, Liu B, Li Z. J Clin Invest. 2015 Feb;125(2):859-69. doi: 10.1172/JCI79014. Epub 2015 Jan 20. PMID:25607841

 

To affinity and beyond: harnessing the T cell receptor for cancer immunotherapy. Thaxton JE, Li Z.

Hum Vaccin Immunother. 2014;10(11):3313-21. doi: 10.4161/21645515.2014.973314. Review. PMID:25483644

 

Deletion of CD24 impairs development of heat shock protein gp96-driven autoimmune disease through expansion of myeloid-derived suppressor cells. Thaxton JE, Liu B, Zheng P, Liu Y, Li Z. J Immunol. 2014 Jun 15;192(12):5679-86. doi: 10.4049/jimmunol.1302755. Epub 2014 May 7. PMID:24808359

 

NKG2D blockade inhibits poly(I:C)-triggered fetal loss in wild type but not in IL-10-/- mice. Thaxton JE, Nevers T, Lippe EO, Blois SM, Saito S, Sharma S. J Immunol. 2013 Apr 1;190(7):3639-47. doi: 10.4049/jimmunol.1203488. Epub 2013 Mar 1. PMID:23455498

 

TLR-mediated preterm birth in response to pathogenic agents. Thaxton JE, Nevers TA, Sharma S.

Infect Dis Obstet Gynecol. 2010;2010. pii: 378472. doi: 10.1155/2010/378472. Epub 2010 Aug 23. Review. PMID:20827416

 

Interleukin-10: a multi-faceted agent of pregnancy. Thaxton JE, Sharma S. Am J Reprod Immunol. 2010 Jun;63(6):482-91. doi: 10.1111/j.1600-0897.2010.00810.x. Epub 2010 Feb 16. Review. PMID:20163400

 

TLR9 activation coupled to IL-10 deficiency induces adverse pregnancy outcomes. Thaxton JE, Romero R, Sharma S.

J Immunol. 2009 Jul 15;183(2):1144-54. doi: 10.4049/jimmunol.0900788. Epub 2009 Jun 26. PMID:19561095

Increased CD4+Foxp3+ T cells in BAFF-transgenic mice suppress T cell effector responses. Walters S1, Webster KESutherland AGardam SGroom JLiuwantara DMariño E, Thaxton JWeinberg AMackay FBrink RSprent JGrey STJ Immunol. 2009 Jan 15;182(2):793-801.

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Medical University of South Carolina

Department of Orthopaedics

© Last updated April 2020