Thaxton Lab | Publications

top of page

Exhaustion

Exhaustion

TRANSLATIONAL TUMOR IMMUNOTHERAPY RESEARCH

UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

LINEBERGER COMPREHENSIVE CANCER CENTER

PI: JESSICA THAXTON, PHD, MSCR

Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4

Enhancer driven.png

Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment

Atlas guided.png

Atlas-guided discovery of transcription factors for T cell programming

Acetyl-CoA carboxylase obstructs CD8+ T cell lipid utilization in the tumor microenvironment

Cell Metabolism, 2024

Progressively enhancing.png

Progressively Enhancing Stemness of Adoptively Transferred T Cells with PI3Kδ Blockade Improves Metabolism and Antitumor Immunity

Cancer Research, 2024

Stress mediated.png

Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer

Cancer Research, 2022

The ER-mitochondria interface.png

The ER-Mitochondria Interface as a Dynamic Hub for T Cell Efficacy in Solid Tumors

Frontiers in Cell and Developmental Biology, 2022

Immune responses.png

Immune Responses Vary in Preinvasive Colorectal Lesions by Tumor Location and Histology

Cancer Prevention Research, 2021

Fundamentals of T cell.png

Fundamentals of T Cell Metabolism and Strategies to Enhance Cancer Immunotherapy

Frontiers in Immunology, 2021

B cells imprint.png

B cells imprint adoptively transferred CD8+ T cells with enhanced tumor immunity

Journal for Immunotherapy of Cancer, 2022

Stress relief.png

Stress relief for cancer immunotherapy: implications for the ER stress response in tumor immunity

Cancer Immunology, Immunotherapy, 2020

Targeting immunosuppressive macrophages.png

Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer

Nature Cancer, 2021

Ex vivo blockade of PI3K.png

Ex vivo blockade of PI3K gamma or delta signaling enhances the antitumor potency of adoptively transferred CD8+ T cells

European Journal of Immunology, 2020

An observational study health psychology.png

An observational study and randomized trial of stress reactivity in cancer disparities

Health Psychology, 2020

Remodeling translation.png

Remodeling Translation Primes CD8+ T-cell Antitumor Immunity

Cancer Immunology Research, 2020

ER stress contributes.png

Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8+ T Cells

Cancer Immunology Research, 2019

bottom of page