Acetyl-CoA Carboxylase Obstructs CD8+ T cell Lipid Utilization in the Tumor Microenvironment. Hunt EG, Hurst KE, Riesenberg BP, Kennedy AS, Gandy EJ, Andrews AM, Alicea Pauneto CDM, Ball LE, Wallace ED, Gao P, Meier J, Serody JJ, Coleman MF, Thaxton JE. In Press, Cell Metabolism.

 

Progressively Enhancing Stemness of Adoptively Transferred T cells with PI3K Blockade Improves Metabolism and Antitumor Immunity. Rangel River GO, Dwyer CJ, Knochelmann HM, Smith AS, Aksoy BA, Cole A, Wyatt MM, Kumaresan S, Thaxton JE, Lesinski G, Paulos CM. Cancer Res, 2024 Jan 2;84(1):69-83. doi: 10.1158/0008-5472.CAN-23-0801

 

Stress-mediated Annenuation of Translation Undermines T-cell Activity in Cancer. Riesenberg BP, Hunt EG, Tennant MD, Hurst KE, Andrews AM, Leddy LR, Neskey DM, Hill EG, Rivera GOR, Paulos CM, Gao P, Thaxton JE. Cancer Res, 2022 Dec 2;82(23):4386-4399. doi: 10.1158/0008-5472.CAN-22-1744. PMID: 36126165

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The ER-Mitochondria Interface as a Dynamic Hub for T Cell Efficacy in Solid Tumors. Hunt EG, Andrews AM, Larsen SR, Thaxton JE. Front Cell Dev Biol 2022 Apr 27; 10:867341. doi: 10.3389/fcell.2022.867341. PMID: 35574704

 

Immune Responses Vary in Preinvasive Colorectal Lesions by Tumor Location and Histology. Wallace K, El Nahas GJ, Bookhout C, Thaxton JE, Lewin DN, Nikolaishvili-Feinberg N, Cohen SM, Brazeal JG, Hill EG,  Wu JD,  Baron JA, Alekseyenko  AV. Cancer Prev Res, 2021 Sep;14(9):885-892. doi: 10.1158/1940-6207.CAPR-20-0592. PMID: 34341013

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Fundamentals of T Cell Metabolism and Strategies to Enhance Cancer Immunotherapy. Rangel Rivera GO, Knochelmann HM, Dwyer CJ, Smith AS, Wyatt MM, Rivera-Reyes AM, Thaxton JE, Paulos CM. Front Immunol, 2021 Mar 18;12:645242. doi: 10.3389/fimmu.2021.645242. PMID: 33815400

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B cells imprint adoptively transferred CD8 + T cells with enhanced tumor immunity. Smith AS, Knochelmann HM,  Wyatt MM, Rangel Rivera GO, Rivera-Reyes AM, Dwyer CJ, Ware MB, Cole AC, Neskey DM, Rubinstein MP, Liu B, Thaxton JE, Bartee E, Paulos CM. J Immunother Cancer, 2022 Jan;10(1):e003078. doi: 10.1136/jitc-2021-003078. PMID: 35017148

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Stress relief for cancer immunotherapy: Implications for the ER stress response in tumor immunity. Andrews AM, Tennant MD, Thaxton JE. Metabolic stress relief for cancer immunotherapy. Cancer Immunology and Immunotherapy, 2021 May;70(5):1165-1175. doi: 10.1007/s00262-020-02740-3. Epub 2020 Oct 26.PMID: 33104836 

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Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer. Mehta AK, Cheney EM, Hartl CA, Pantelidou C, Oliwa M, Castrillon JA, Lin JR, Hurst KE, de Oliveira Taveira M, Johnson NT, Oldham WM, Kalocsay M, Berberich MJ, Boswell SA, Kothari A, Johnson S, Dillon DA, Lipschitz M, Rodig S, Santagata S, Garber JE, Tung N, Yélamos J, Thaxton JE, Mittendorf EA, Sorger PK, Shapiro GI, Guerriero JL.Nat Cancer. 2021 Jan;2(1):66-82. doi: 10.1038/s43018-020-00148-7. Epub 2020 Dec 14.PMID: 33738458

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Ex vivo blockade of PI3K gamma or delta signaling enhances the antitumor potency of adoptively transferred CD8+ T cells. Dwyer CJ, Arhontoulis DC, Rangel Rivera GO, Knochelmann HM, Smith AS, Wyatt MM, Rubinstein MP, Atkinson C, Thaxton JE, Neskey DM, Paulos CM. Eur J Immunol. 2020 May 08

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An observational study and randomized trial of stress reactivity in cancer disparities. Hughes-Halbert C, Jefferson MS, Danielson CC, Foglier B, Giordano A, Thaxton JE. Health Psychol. 2020 Sep;39(9):745-757. doi: 10.1037/hea0000882. PubMed PMID: 32833476

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Remodeling Translation Primes CD8+ T Cell Antitumor Immunity. Hurst KE, Lawrence KA, Robino RA, Ball LE, Chung D, Thaxton JE. Cancer Immunol Res. 2020 May;8(5):587-595. doi: 10.1158/2326-6066.CIR-19-0516. Epub 2020 Feb 19. PubMed PMID: 32075802.

 

Endoplasmic Reticulum Protein Disulfide Isomerase Shapes T Cell Efficacy for Adoptive Cellular Therapy of Tumors. Hurst KE, Lawrence KA, Reyes Angeles L, Ye Z, Zhang J, Townsend DM, Dolloff N, Thaxton JE. Cells. 2019 Nov 26;8(12). pii: E1514. doi: 10.3390/cells8121514

 

Endoplasmic reticulum stress contributes to mitochondrial exhaustion of T cells. Hurst, KE, Lawrence, KA, Essman, MT, Walton, ZJ, Leddy, LR, Thaxton, JE. Cancer Immunol Res. 2019 Mar;7(3):476-486. doi: 10.1158/2326-6066.CIR-18-0182. Epub 2019 Jan 18. PMID:30659052

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Modulation of endoplasmic reticulum stress controls CD4+ T-cell activation and antitumor function. Thaxton JE, Wallace C, Riesenberg B, Zhang Y, Paulos CM, Beeson CC, Liu B, Li Z. Cancer Immunol Res. 2017 Aug;5(8):666-675. doi: 10.1158/2326-6066.CIR-17-0081. Epub 2017 Jun 22. PMID:28642246

 

Clients and oncogenic roles of molecular chaperone gp96/grp94. Ansa-Addo EA, Thaxton J, Hong F, Wu BX, Zhang Y, Fugle CW, Metelli A, Riesenberg B, Williams K, Gewirth DT, Chiosis G, Liu B, Li Z. Curr Top Med Chem. 2016;16(25):2765-78. Review. PMID:27072698

 

GP96 is a GARP chaperone and controls regulatory T cell functions. Zhang Y, Wu BX, Metelli A, Thaxton JE, Hong F, Rachidi S, Ansa-Addo E, Sun S, Vasu C, Yang Y, Liu B, Li Z. J Clin Invest. 2015 Feb;125(2):859-69. doi: 10.1172/JCI79014. Epub 2015 Jan 20. PMID:25607841

 

To affinity and beyond: harnessing the T cell receptor for cancer immunotherapy. Thaxton JE, Li Z.

Hum Vaccin Immunother. 2014;10(11):3313-21. doi: 10.4161/21645515.2014.973314. Review. PMID:25483644

 

Deletion of CD24 impairs development of heat shock protein gp96-driven autoimmune disease through expansion of myeloid-derived suppressor cells. Thaxton JE, Liu B, Zheng P, Liu Y, Li Z. J Immunol. 2014 Jun 15;192(12):5679-86. doi: 10.4049/jimmunol.1302755. Epub 2014 May 7. PMID:24808359

 

NKG2D blockade inhibits poly(I:C)-triggered fetal loss in wild type but not in IL-10-/- mice. Thaxton JE, Nevers T, Lippe EO, Blois SM, Saito S, Sharma S. J Immunol. 2013 Apr 1;190(7):3639-47. doi: 10.4049/jimmunol.1203488. Epub 2013 Mar 1. PMID:23455498

 

TLR-mediated preterm birth in response to pathogenic agents. Thaxton JE, Nevers TA, Sharma S.

Infect Dis Obstet Gynecol. 2010;2010. pii: 378472. doi: 10.1155/2010/378472. Epub 2010 Aug 23. Review. PMID:20827416

 

Interleukin-10: a multi-faceted agent of pregnancy. Thaxton JE, Sharma S. Am J Reprod Immunol. 2010 Jun;63(6):482-91. doi: 10.1111/j.1600-0897.2010.00810.x. Epub 2010 Feb 16. Review. PMID:20163400

 

TLR9 activation coupled to IL-10 deficiency induces adverse pregnancy outcomes. Thaxton JE, Romero R, Sharma S.

J Immunol. 2009 Jul 15;183(2):1144-54. doi: 10.4049/jimmunol.0900788. Epub 2009 Jun 26. PMID:19561095

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Increased CD4+Foxp3+ T cells in BAFF-transgenic mice suppress T cell effector responses. Walters S1, Webster KE, Sutherland A, Gardam S, Groom J, Liuwantara D, Mariño E, Thaxton J, Weinberg A, Mackay F, Brink R, Sprent J, Grey ST. J Immunol. 2009 Jan 15;182(2):793-801.