Exhaustion
Exhaustion
Adoptively transferred T cells with progressively enhanced stemness have improved metabolic properties and tumor immunity. Rangel River GO, Dwyer CJ, Knochelmann HM, Smith AS, Aksoy BA, Cole A, Wyatt MM, Thaxton JE, Lesinski G, Paulos CM. In Press, Cancer Research.
The ER-Mitochondria Interface as a Dynamic Hub for T Cell Efficacy in Solid Tumors. Hunt EG, Andrews AM, Larsen SR, Thaxton JE. Front Cell Dev Biol 2022 Apr 27; 10:867341. doi: 10.3389/fcell.2022.867341. PMID: 35574704
Immune Responses Vary in Preinvasive Colorectal Lesions by Tumor Location and Histology. Wallace K, El Nahas GJ, Bookhout C, Thaxton JE, Lewin DN, Nikolaishvili-Feinberg N, Cohen SM, Brazeal JG, Hill EG, Wu JD, Baron JA, Alekseyenko AV. Cancer Prev Res, 2021 Sep;14(9):885-892. doi: 10.1158/1940-6207.CAPR-20-0592. PMID: 34341013
Fundamentals of T Cell Metabolism and Strategies to Enhance Cancer Immunotherapy. Rangel Rivera GO, Knochelmann HM, Dwyer CJ, Smith AS, Wyatt MM, Rivera-Reyes AM, Thaxton JE, Paulos CM. Front Immunol, 2021 Mar 18;12:645242. doi: 10.3389/fimmu.2021.645242. PMID: 33815400
B cells imprint adoptively transferred CD8 + T cells with enhanced tumor immunity. Smith AS, Knochelmann HM, Wyatt MM, Rangel Rivera GO, Rivera-Reyes AM, Dwyer CJ, Ware MB, Cole AC, Neskey DM, Rubinstein MP, Liu B, Thaxton JE, Bartee E, Paulos CM. J Immunother Cancer, 2022 Jan;10(1):e003078. doi: 10.1136/jitc-2021-003078. PMID: 35017148
Stress relief for cancer immunotherapy: Implications for the ER stress response in tumor immunity. Andrews AM, Tennant MD, Thaxton JE. Metabolic stress relief for cancer immunotherapy. Cancer Immunology and Immunotherapy, 2021 May;70(5):1165-1175. doi: 10.1007/s00262-020-02740-3. Epub 2020 Oct 26.PMID: 33104836
Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer. Mehta AK, Cheney EM, Hartl CA, Pantelidou C, Oliwa M, Castrillon JA, Lin JR, Hurst KE, de Oliveira Taveira M, Johnson NT, Oldham WM, Kalocsay M, Berberich MJ, Boswell SA, Kothari A, Johnson S, Dillon DA, Lipschitz M, Rodig S, Santagata S, Garber JE, Tung N, Yélamos J, Thaxton JE, Mittendorf EA, Sorger PK, Shapiro GI, Guerriero JL.Nat Cancer. 2021 Jan;2(1):66-82. doi: 10.1038/s43018-020-00148-7. Epub 2020 Dec 14.PMID: 33738458
Ex vivo blockade of PI3K gamma or delta signaling enhances the antitumor potency of adoptively transferred CD8+ T cells. Dwyer CJ, Arhontoulis DC, Rangel Rivera GO, Knochelmann HM, Smith AS, Wyatt MM, Rubinstein MP, Atkinson C, Thaxton JE, Neskey DM, Paulos CM. Eur J Immunol. 2020 May 08
An observational study and randomized trial of stress reactivity in cancer disparities. Hughes-Halbert C, Jefferson MS, Danielson CC, Foglier B, Giordano A, Thaxton JE. Health Psychol. 2020 Sep;39(9):745-757. doi: 10.1037/hea0000882. PubMed PMID: 32833476
Remodeling Translation Primes CD8+ T Cell Antitumor Immunity. Hurst KE, Lawrence KA, Robino RA, Ball LE, Chung D, Thaxton JE. Cancer Immunol Res. 2020 May;8(5):587-595. doi: 10.1158/2326-6066.CIR-19-0516. Epub 2020 Feb 19. PubMed PMID: 32075802.
Endoplasmic Reticulum Protein Disulfide Isomerase Shapes T Cell Efficacy for Adoptive Cellular Therapy of Tumors. Hurst KE, Lawrence KA, Reyes Angeles L, Ye Z, Zhang J, Townsend DM, Dolloff N, Thaxton JE. Cells. 2019 Nov 26;8(12). pii: E1514. doi: 10.3390/cells8121514
Endoplasmic reticulum stress contributes to mitochondrial exhaustion of T cells. Hurst, KE, Lawrence, KA, Essman, MT, Walton, ZJ, Leddy, LR, Thaxton, JE. Cancer Immunol Res. 2019 Mar;7(3):476-486. doi: 10.1158/2326-6066.CIR-18-0182. Epub 2019 Jan 18. PMID:30659052
Modulation of endoplasmic reticulum stress controls CD4+ T-cell activation and antitumor function. Thaxton JE, Wallace C, Riesenberg B, Zhang Y, Paulos CM, Beeson CC, Liu B, Li Z. Cancer Immunol Res. 2017 Aug;5(8):666-675. doi: 10.1158/2326-6066.CIR-17-0081. Epub 2017 Jun 22. PMID:28642246
Clients and oncogenic roles of molecular chaperone gp96/grp94. Ansa-Addo EA, Thaxton J, Hong F, Wu BX, Zhang Y, Fugle CW, Metelli A, Riesenberg B, Williams K, Gewirth DT, Chiosis G, Liu B, Li Z. Curr Top Med Chem. 2016;16(25):2765-78. Review. PMID:27072698
GP96 is a GARP chaperone and controls regulatory T cell functions. Zhang Y, Wu BX, Metelli A, Thaxton JE, Hong F, Rachidi S, Ansa-Addo E, Sun S, Vasu C, Yang Y, Liu B, Li Z. J Clin Invest. 2015 Feb;125(2):859-69. doi: 10.1172/JCI79014. Epub 2015 Jan 20. PMID:25607841
To affinity and beyond: harnessing the T cell receptor for cancer immunotherapy. Thaxton JE, Li Z.
Hum Vaccin Immunother. 2014;10(11):3313-21. doi: 10.4161/21645515.2014.973314. Review. PMID:25483644
Deletion of CD24 impairs development of heat shock protein gp96-driven autoimmune disease through expansion of myeloid-derived suppressor cells. Thaxton JE, Liu B, Zheng P, Liu Y, Li Z. J Immunol. 2014 Jun 15;192(12):5679-86. doi: 10.4049/jimmunol.1302755. Epub 2014 May 7. PMID:24808359
NKG2D blockade inhibits poly(I:C)-triggered fetal loss in wild type but not in IL-10-/- mice. Thaxton JE, Nevers T, Lippe EO, Blois SM, Saito S, Sharma S. J Immunol. 2013 Apr 1;190(7):3639-47. doi: 10.4049/jimmunol.1203488. Epub 2013 Mar 1. PMID:23455498
TLR-mediated preterm birth in response to pathogenic agents. Thaxton JE, Nevers TA, Sharma S.
Infect Dis Obstet Gynecol. 2010;2010. pii: 378472. doi: 10.1155/2010/378472. Epub 2010 Aug 23. Review. PMID:20827416
Interleukin-10: a multi-faceted agent of pregnancy. Thaxton JE, Sharma S. Am J Reprod Immunol. 2010 Jun;63(6):482-91. doi: 10.1111/j.1600-0897.2010.00810.x. Epub 2010 Feb 16. Review. PMID:20163400
TLR9 activation coupled to IL-10 deficiency induces adverse pregnancy outcomes. Thaxton JE, Romero R, Sharma S.
J Immunol. 2009 Jul 15;183(2):1144-54. doi: 10.4049/jimmunol.0900788. Epub 2009 Jun 26. PMID:19561095
Increased CD4+Foxp3+ T cells in BAFF-transgenic mice suppress T cell effector responses. Walters S1, Webster KE, Sutherland A, Gardam S, Groom J, Liuwantara D, Mariño E, Thaxton J, Weinberg A, Mackay F, Brink R, Sprent J, Grey ST. J Immunol. 2009 Jan 15;182(2):793-801.
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