Exhaustion
Exhaustion
Jessica Thaxton, PhD, MsCR
Principal Investigator
Dr. Thaxton is an Associate Professor in the Department of Cell Biology and Physiology at the University of North Carolina at Chapel Hill. Dr. Thaxton received her BA from Amherst College and her PhD from Brown University in Pathobiology & Immunology. Dr. Thaxton trained as a postdoctoral fellow in the field of ER stress and Immunity in the laboratory of Zihai Li, MD, PhD. During her postdoctoral work Dr. Thaxton held a Department of Defense Breast Cancer Postdoctoral Research Fellowship and obtained a Master's in Clinical Research in the study of clinical trials. As an Assistant Professor Dr. Thaxton’s work on tumor-induced ER dysfunction in tumor infiltrating T cells was supported by the NCI Paul Calabresi Clinical Oncology K12 Fellowship. The Thaxton lab has delineated negative roles for the PERK axis in T cell-mediated tumor immunity and continues to study how the solid tumor microenvironment undermines immune-mediated tumor control through dysregulation of ER stress signaling, ER structure, and proteostasis.
Research Team
Katie Hurst, MPH
Lab Manager
Katie graduated from Clemson University with a BA in Biological Sciences with a minor in Psychology. Katie’s interest in cancer biology led her to the Medical University of South Carolina after graduation to pursue a career in molecular cancer research, whereafter she transitioned into cancer immunology research. She holds a special interest in the patient psychological response to cancer and how the immune system can regulate this response and vice versa. Katie serves as lab manager for the Thaxton Lab during which she pursued her Masters in Public Health with a concentration in Health Behavior at the Medical University of South Carolina, where she graduated in 2020.
Genevieve Clutton, DPhil
Research Associate
Dr. Clutton received her BS from the University of Bath (UK) and her DPhil (PhD) in Immunology from the University of Oxford (UK). She trained as a postdoctoral fellow in the laboratory of Dr. Nilu Goonetilleke, PhD at the University of North Carolina at Chapel Hill, investigating CD8 T cell responses to HIV-1 and other viruses. She obtained independent funding to study T cell responses in the context of Kaposi’s sarcoma and obesity, which fueled her interest in the effects of metabolism on the efficacy of T cell therapies
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Coral Del Mar Alicea Pauneto, PhD
Postdoctoral Scholar
Dr. Alicea Pauneto graduated from the University of Puerto Rico at Humacao in 2015 with a BS in Industrial Chemistry. During her undergraduate year, she did multiple research internships in neuroscience and pharmacology leading her to pursue graduate studies. After graduating, she was accepted into the Pharmacology department at UNC with an interest in neuro-oncology and cancer immunotherapy. At the beginning of her graduate student career, she focused on studying myeloid-directed immunotherapy to treat medulloblastoma. After this experience, she pursued her interest in understanding immunotherapy from a cell biology perspective, where she then joined the Thaxton lab. Coral studies the chronic role of ATF4, a transcription factor important in endoplasmic reticulum stress in tumor-infiltrating T cells, with the ultimate goal of discovering an immunotherapy target.
Andrew Kennedy, PhD
Postdoctoral Scholar
Dr. Kennedy graduated from UNC-Chapel Hill with a BS in Biology in 2016, where he studied the effects of electronic cigarettes on lung disease. After graduation he led projects as a research technician studying the interplay between endoplasmic reticulum quality control and autophagy within protein-misfolding diseases. After becoming a PhD candidate in UNC's Cell Biology and Physiology department, Andrew joined the Thaxton lab to apply his interest in endoplasmic reticulum biology for the improvement of cancer immunotherapies.
Jessie Hem
Graduate Student
Jessie graduated from Williams College in 2021 with a BA in Biology. During her time at Williams, she wrote an undergraduate thesis in plant biochemistry, taught science to 5th grade students, and played varsity lacrosse. Upon graduating, she moved to Boston where she worked as a research technician for three years at Brigham and Women's Hospital studying myeloproliferative neoplasms. After starting graduate school at UNC, Jessie wanted to pursue the field of tumor immunology and metabolism and joined the Thaxton Lab. Jessie studies altered lipid metabolism as a result of chronic endoplasmic reticulum stress in tumor-infiltrating T cells with the goal of finding new targets to improve immunotherapy.
Lindsay Sheft
Graduate Student
Lindsay graduated from Boston College in 2023 with a BS in Biochemistry. At Boston College, Lindsay worked in the Student Admission Office, led community service trips, and mentored and served as a teaching assistant for younger students. After graduation, Lindsay worked as a Research Associate at the Broad Institute of MIT and Harvard University for two years. She worked on generating novel patient-derived cancer cell models and identifying colocalized surface protein targets in specific tumor subtypes. In the Thaxton Lab, Lindsay studies how metabolic stress in the tumor microenvironment alters tumor associated macrophage metabolism and drives immunosuppressive functions.
Ryan Hagle
Graduate Student
Ryan graduated from the University of Wisconsin-Madison in 2022 with a BS in Biochemistry. During his undergraduate, he completed a senior thesis in a lab researching the role of neurons in zebrafish tissue regeneration. After graduating, Ryan moved to the Washington DC area to work for two years at AstraZeneca on their Autologous CAR-T Process Development team. While there, he also took advantage of what the area had to offer including hiking, restaurants, and events/festivals. Ryan moved to Chapel Hill in 2025 to begin his PhD training in the Thaxton Lab through the Department of Microbiology and Immunology. His thesis work is focused on the immunometabolic role of the endoplasmic reticulum in human CAR-T cells.
Sumita Trivedi, MD
Clinical Scientist
Dr. Trivedi is a head and neck medical oncologist and Assistant Professor of Medicine in the Division of Medical Oncology at UNC-Chapel Hill. She received her MD from St. George's University of London and completed her residency at Emory University and fellowship at University of Pennsylvania. She trained in cancer immunology and immunotherapy in the laboratory of Dr. Robert Ferris at the University of Pittsburgh, where she studied immune responses to monoclonal antibodies used in head and neck cancer (HNSCC) patients. At University of Pennsylvania Dr. Trivedi developed a novel CAR-T cell to treat head and neck cancers in the laboratory of Dr. Steven Albelda. At UNC-Chapel Hill LCCC, Dr. Trivedi continues her research through a K award that supports her development of novel treatment strategies and clinical trials in HNSCC patients.
K9 Unit (& cats)
Julie Millie Cal & Morrie Kona
Bruin, Bauer, & Buddy Ozzy