Two R01 grants have been awarded by NCI/NIH to the Thaxton lab in 2020 as part of the Cancer Moonshot Initiative on Immunometabolism!
1RO1CA348359-010: 4/01/2020 - 03/31/2025
Title: Exploitation of ER Stress Induced Immune Dysfunction to Improve Cancer Immunotherapy
1R01CA244361-01A1: 7/1/20 - 6/30/25
Title: Targeting Chronic ER Stress in T-Cells to Improve Cancer Immunotherapy
Congratulations to the lab of Dr. Jennifer Guerriero on acceptance of their paper titled "Differentiating macrophages are regulated by PARP inhibitors and can be harnessed to overcome PARP-inhibitor resistance in BRCA-associated triple-negative breast cancer" in press in Nature Cancer.
Differentiating macrophages are regulated by PARP inhibitors and can be harnessed to overcome PARP-inhibitor resistance in BRCA-associated triple-negative breast cancer. Mehta AK, Cheney EM, Hartl CA, Pantelidou C, Oliwa M, Castrillon JA, Lin J, Hurst KE, de Oliveira Taveira M, Johnson N, Oldham W, Thaxton JE, Mittendorf EA, Shapiro GI, Sorger PK, Guerriero JL. Nature Cancer, In Press. Forthcoming
The Thaxton lab has received the MUSC Foundation for Research Development Award for 02/01/2020 – 01/31/2021
Title: Development of Novel Inhibitors to Target Cell Stress Response
The major goal of this project is to use medicinal chemistry to generate inhibitors that target the cell stress response in immune cells.
Dr. Thaxton gives an oral presentation at the Hollings Cancer Center Cancer Biology & Cancer Immunology Research Retreat where she shares her lab's most recent discoveries about T cell translation under stress
Dr. Thaxton sits down with Charleston local Cokie Berenyi for an episode of Perfect Day Podcast where they discuss cancer immunology research and what is on the horizon in novel cancer immunotherapies.
Dr. Thaxton's team SITCure wins Sparkathon!
Dr. Thaxton gives oral presentation on ER stress in TILs at SITC annual meeting