Exhaustion
Exhaustion
TRANSLATIONAL TUMOR IMMUNOTHERAPY RESEARCH
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
LINEBERGER COMPREHENSIVE CANCER CENTER
PI: JESSICA THAXTON, PHD, MSCR
Metabolic Reprogramming of Immunity
Metabolism of tumor infiltrating T cells (TILs) and tumor associated macrophages defines their antitumor capacity.
We study how immune cell stress in the tumor microenvironment programs aberrant metabolism in CD8+ TILs and tumor associated macrophages to limit response to checkpoint therapies.
We continue to study the role of lipogenesis to aberrantly program immune cell fate and function in tumors. Our latest work in Cell Metabolism details the role of the tumor microenvironment to drive the metabolic enzyme ACC to promote lipid accumulation in T cells in tumors.